Engineering of Biomolecular Energy Conversion and Transport Modules for the Assembly of Molecular Factories

Schematic representation of a ‘simple’ biomolecular factory: The reactor is a nanocontainer (made of lipid or block copolymer) equipped with light-driven proton pumps (in red; energizing modules), proton-driven solute transporters (in blue; translocating modules) and metabolizing enzymes (in brown; metabolizing modules). Such light powered nanoreactors will import specific solutes from a solution and degrade them inside. Possible application: decontamination of water/solutions from toxic compounds or pollutant.
Schematic representation of a ‘simple’ biomolecular factory: The reactor is a nanocontainer (made of lipid or block copolymer) equipped with light-driven proton pumps (in red; energizing modules), proton-driven solute transporters (in blue; translocating modules) and metabolizing enzymes (in brown; metabolizing modules). Such light powered nanoreactors will import specific solutes from a solution and degrade them inside. Possible application: decontamination of water/solutions from toxic compounds or pollutant.

NCCR Molecular Systems Engineering combines expertise from chemistry, biology, physics, bioinformatics, and engineering. The overreaching aim is to develop tools and devices to monitor and manipulate off-equilibrium (bio)chemical systems. In this manner, it should be possible to create molecular factories and cellular systems whose properties are more than sum of the attributes of the individual modules. These new system-level properties emerge through the interactions of chemical- and biological networks and may find applications in the synthesis of high added-value products, as innovative diagnostic tools and for the restoration of a desired cellular or organ function.

The research carried out within NCCR Molecular Systems Engineering consists of Research Projects divided into three Work Packages.

Each Research Project is headed by a Project Leader, who supervises fellows paid by NCCR funds and associated fellows that are involved in the research of the NCCR but are financed by other sources.

Eleven Joint Research Projects are headed by two (or more) Project Leaders and are usually associated with more than one Work Package.

Project Leader

Dimitrios Fotiadis

Scientific publications

Find a list of all scientific publications here.

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