Randall Platt - NCCR MSE

Randall Platt

Department of Biosystems Science and Engineering (D-BSSE), ETH Zurich

 Project Leader

Contact

rplatt(at)ethz.ch

Platt group @D-BSSE

Publications

O. Belli, K. Karava, R. Farouni, R. Platt “Multimodal scanning of genetic variants with base and prime editing“ Nat. Biotechnol. 2024. [DOI]
P. Abe, A. Lavalley, I. Morassut, A. J. Santinha, S. Roig-Puiggros, A. Javed, E. Klingler, N. Baumann, J. Prados, R. Platt, D. Jabaudon “Molecular programs guiding arealization of descending cortical pathways“ Nature 2024. [DOI]
E. Kapetanovic, C. R. Weber, M. Bruand, D. Poschl, J. Kucharczyk, E. Hirth, C. Dietsche, R. Khan, B. Wagner, O. Belli, R. Vazquez-Lombardi, R. Castellanos-Rueda, R. B. Di Roberto, K. Kalinka, L. Raess, K. Ly, S. Rai, P. Dittrich, R. Platt, E. Oricchio, S. Reddy “Engineered allogeneic T cells decoupling T-cell-receptor and CD3 signalling enhance the antitumour activity of bispecific antibodies“ Nat. Biomed. Eng. 2024. [DOI]
C. Borrelli, M. Roberts, D. Eletto, M. D. Hussherr, H. Fazilaty, T. Valenta, A. Lafzi, J. A. Kretz, E. Guido Vinzoni, A. Karakatsani, S. Adivarahan, A. Mannhart, S. Kimura, A. Meijs, F. Baccouche Mhamedi, I. E. Acar, K. Handler, X. Ficht, R. Platt, S. Piscuoglio, A. E. Moor “In vivo interaction screening reveals liver-derived constraints to metastasis“ Nature 2024. [DOI]
N. Franko, A. J. da Silva Santinha, S. Xue, H. Zhao, G. Charpin-El Hamri, R. Platt, A. P. Teixeira, M. Fussenegger “Integrated compact regulators of protein activity enable control of signaling pathways and genome-editing in vivo“ Cell Discov. 2024. [DOI]
A. J. Santinha, E. Klingler, M. Kuhn, R. Farouni, S. Lagler, G. Kalamakis, U. Lischetti, D. Jabaudon, R. Platt “Transcriptional linkage analysis with in vivo AAV-Perturb-seq“ Nature 2023. [DOI]
G. Kalamakis, R. Platt “CRISPR for neuroscientists“ Neuron 2023. [DOI]
R. Platt “Noninvasive assessment of gut function using transcriptional recording sentinel cells“ Science 2022. [DOI]
N. R. Weisbach, A. Meijs, R. Platt “Multiplexed Genome Engineering with Cas12a“ 2022. [DOI]
M. Y. Cherepkova, T. Tanna, R. Platt “Recording Biological Information with CRISPR - Cas Systems“ Crispr 2022. [DOI]
M. Kuhn, A. J. Santinha, R. Platt “Moving from in vitro to in vivo CRISPR screens“ Gene and Genome Editing 2021. [DOI]
E. Klingler, U. Tomasello, J. Prados, J. M. Kebschull, A. Contestabile, G. L. Galiñanes, S. Fièvre, A. Santinha, R. Platt, D. Huber, A. Dayer, C. Bellone, D. Jabaudon “Temporal controls over inter-areal cortical projection neuron fate diversity“ Nature 2021. [DOI]
T. Tanna, R. Ramachanderan, R. Platt “Engineered bacteria to report gut function: technologies and implementation“ Curr. Opin. Microbiol. 2020. [DOI]
T. Tanna, F. Schmidt, M. Y. Cherepkova, M. Okoniewski, R. Platt “Recording transcriptional histories using Record-seq“ Nat. Protoc. 2020. [DOI]
J. G. Camp, R. Platt, B. Treutlein “Mapping human cell phenotypes to genotypes with single-cell genomics“ 2019. [DOI]
C. C. Campa, N. R. Weisbach, A. J. Santinha, D. Incarnato, R. Platt “Multiplexed Genome Engineering by Cas12a and CRISPR Arrays Encoded on Single Transcripts“ Nat. Methods 2019. [DOI]
F. Schmidt, M. Y. Cherepkova, R. Platt “Transcriptional recording by CRISPR spacer acquisition from RNA“ Nature 2018. [DOI]
G. Wang, R. D. Chow, L. Ye, C. D. Guzman, X. Dai, M. B. Dong, F. Zhang, P. A. Sharp, R. Platt, S. Chen “Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR–mediated direct in vivo screening“ Sci. Adv. 2018. [DOI]
R. D. Chow, C. D. Guzman, G. Wang, F. Schmidt, M. W. Youngblood, L. Ye, Y. Errami, M. B. Dong, M. A. Martinez, F. Zhang, P. Renauer, K. Bilguvar, M. Gunel, P. A. Sharp, R. Platt, S. Chen “AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma“ Nat. Neurosci. 2017. [DOI]
F. Schmidt, R. Platt “Applications of CRISPR-Cas for synthetic biology and genetic recording“ Curr. Opin. Syst. Biol. 2017, 5:9-15. [DOI]
R. Platt, Y. Zhou, I. M. Slaymaker, A. S. Shetty, N. R. Weisbach, J. Kim, J. Sharma, M. Desai, S. Sood, H. R. Kempton, G. R. Crabtree, G. Feng, F. Zhang “Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits“ Cell Rep. 2017, 19:335-50. [DOI]