Stem Cell and Tissue Engineering - NCCR MSE

Stem Cell and Tissue Engineering

Our lab has pioneered the use of direct perfusion of fluid through the matrix of engineered tissues to mimic interstitial fluid flow within custom-designed bioreactor chambers in order to generate and sustain uniform tissue structures.

Diabetes mellitus, the complex and multifactorial disease characterized by hyperglycaemia, results from a loss of pancreatic insulin-producing β-cells. However, none of the current cell-based diabetic therapies is autologous; whereas transplantation of pancreatic islets typically suffers from donor scarcity, compatibility and variability in graft quality.

A way to solve these issues is to engineer autologous patient cells to act like healthy pancreatic β-cells and re-implant them. We hypothesize that culture of these genetically programmed pancreatic cells within the developed 3D perfusion-based culture system in co-culture with vascularizing autologous cells will generate micro-tissues with improved in vitro and in vivo functionality.


A. García-García, S. Pigeot, I. Martin “Engineering of immunoinstructive extracellular matrices for enhanced osteoinductivity“ Bioact. Mater. 2023. [DOI]
G. Born, E. Plantier, G. Nannini, A. Caimi, A. Mazzoleni, M. A. Asnaghi, M. G. Muraro, A. Scherberich, I. Martin, A. García-García “Mini- and macro-scale direct perfusion bioreactors with optimized flow for engineering 3D tissues“ Biotechnol. J. 2022. [DOI]
L. Kouba, J. Bürgin, G. Born, G. Perale, D. J. Schaefer, A. Scherberich, S. Pigeot, I. Martin “A composite, off-the-shelf osteoinductive material for large, vascularized bone flap prefabrication“ Acta Biomaterialia 2022. [DOI]
A. García-García, I. Martin “Biomimetic human bone marrow tissues: models to study hematopoiesis and platforms for drug testing“ Mol. Cell. Oncol. 2021. [DOI]
A. García-García, T. Klein, G. Born, M. Hilpert, A. Scherberich, C. Lengerke, R. C. Skoda, P. E. Bourgine, I. Martin “Culturing patient-derived malignant hematopoietic stem cells in engineered and fully humanized 3D niches“ Proc. Natl. Acad. Sci. U.S.A. 2021. [DOI]
G. Born, M. Nikolova, A. Scherberich, B. Treutlein, A. García-García, I. Martin “Engineering of fully humanized and vascularized 3D bone marrow niches sustaining undifferentiated human cord blood hematopoietic stem and progenitor cells“ J. Tissue Eng. 2021. [DOI]
L. Acevedo Rua, M. Mumme, C. Manferdini, S. Darwiche, A. Khalil, M. Hilpert, D. A. Buchner, G. Lisignoli, P. Occhetta, B. von Rechenberg, M. Haug, D. J. Schaefer, M. Jakob, A. Caplan, I. Martin, A. Barbero, K. Pelttari “Engineered nasal cartilage for the repair of osteoarthritic knee cartilage defects“ Sci. Transl. Med. 2021. [DOI]
M. Adelaide Asnaghi, L. J. Power, A. Barbero, M. Haug, R. Köppl, D. Wendt, I. Martin “Biomarker signatures of quality for engineering nasal chondrocyte-derived cartilage“ Front. Bioeng. Biotechnol. 2020. [DOI]
I. Martin, J. Malda, N. C. Rivron “Organs by Design: Can Bioprinting Meet Self-Organization?“ Curr. Opin. Organ. Transplant. 2019. [DOI]

Project Leader

Ivan Martin


Martin group @UniBas