- NCCR MSE

Conformational Thermo-stabilization of Functional Biomolecular Modules and development of light-con-trolled Molecular Switches

Simplified scheme of GPCR signalling: Light or ligand binding triggers a conformational change of the receptor that induces G protein activation.
Simplified scheme of GPCR signalling: Light or ligand binding triggers a conformational change of the receptor that induces G protein activation.
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Publications

D. Ehrenberg, N. Varma, X. Deupi, M. Koyanagi, A. Terakita, G. F. X. Schertler, J. Heberle, E. Lesca “The two-photon reversible reaction of the bistable jumping spider rhodopsin-1“ Biophys. J. 2019. [DOI]
M. Hilbert, A. Noga, D. Frey, V. Hamel, P. Guichard, S. H. Kraatz, M. Pfreundschuh, S. Hosner, I. Flückiger, R. Jaussi, M. M. Wieser, K. M. Thieltges, X. Deupi, D. J. Mülle, R. Kammerer, P. Gönczy, M. Hirono, M. O. Steinmetz, D. J. Müller “SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture“ Nat. Cell Biol. 2016, 18:393. [DOI]
D. Sun, T. Flock, X. Deupi, S. Maeda, M. Matkovic, S. Mendieta, D. Mayer, R. J. Dawson, G. Schertler, M. M. Babu, D. B. Veprintsev “Probing Gαi1 protein activation at single–amino acid resolution“ Nat. Struct. Mol. Biol. 2015, 22:686. [DOI]
F. M. Heydenreich, Z. Vuckovic, M. Matkovic, D. B. Veprintsev “Stabilization of G protein-coupled receptors by point mutations“ Front. Pharmacol. 2015, 6:82. [DOI] [More Information]
D. Milić, D. B. Veprintsev “Large-scale production and protein engineering of G protein-coupled receptors for structural studies“ Front. Pharmacol. 2015, 6:66. [DOI] [More Information]
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