Botond Roska

Friedrich Miescher Institute



+41 61 697 8575

Read more about the Roska-Group here.


Winner of the 2016 Cogan Award

Botond Roska, senior group leader at the FMI and project-leader for the NCCR Molecular Systems Engineering, is a renowned expert in the structure and function of retinal circuits in health and disease. His work has contributed in both a fundamental and highly original manner to our understanding of the function of retinal circuits. In addition, he has used his knowledge of retinal processing and the newly available optogenetic tools to reactivate retinal function, at least partially, in mouse models of blinding retinal diseases. Together with scientist from around the world, but particularly the Vision Institute in Paris, he currently tries to bring this method of vision restoration to patients with retinitis pigmentosa, and other late-onset adult blindness diseases.

The 2016 Cogan Award from the Association of Research in Vision and Ophthalmology now recognizes and highlights these outstanding contributions to the field. With this he joins Ted Drya and Connie Cepko, two thought leaders in the field, who have earlier received this award as well.


A. Drinnenberg, F. Franke, R. K. Morikawa, J. Jüttner, D. Hillier, P. Hantz, A. Hierlemann, R. Azeredo da Silveira, B. RoskaHow Diverse Retinal Functions Arise from Feedback at the First Visual Synapse“ Neuron (2018). [Link]
R. Schubert, S. Trenholm, K. Balint, G. Kosche, C. S. Cowan, M. A. Mohr, M. Munz, D. Martinez-Martin, G. Fläschner, R. Newton, J. Krol, B. G. Scherf, K. Yonehara, A. Wertz, A. Ponti, A. Ghanem, D. Hillier, K. Conzelmann, D. J. MüllerB. RoskaVirus stamping for targeted single-cell infection in vitro and in vivo“ Nat. Biotechnol. (2017). [Link]
J. M. Daum, O. Keles, S. J. B. Holwerda, H. Kohler, F. M. Rijli, M. Stadler, B. RoskaThe formation of the light-sensing compartment of cone photoreceptors coincides with a transcriptional switch“ eLife 6, e31437 (2017). [Link]
D. Hillier, M. Fiscella, A. Drinnenberg, S. Trenholm, S. B. Rompani, Z. Raics, G. Katona, J. Juettner, A. Hierlemann, B. Rozsa, B. RoskaCausal evidence for retina-dependent and -independent visual motion computations in mouse cortex“ Nat. Neurosci. (2017). [Link]
D. Alsteens, R. Newton, R. Schubert, D. Martinez-Martin, M. Delguste, B. RoskaD. J. MüllerNanomechanical mapping of first binding steps of a virus to animal cells“ Nat. Nanotechnol., DOI:10.1038/nnano.2016.228 (2016). [Link]
K. Yonehara1, M. Fiscella, A. Drinnenberg, F. Esposti, S. Trenholm, J. Krol, F. Franke, C. Gross Scherf, A. Kusnyerik, J. Müller, A. Szabo, J. Jüttner, F. Cordoba, A. P. Reddy, J. Németh, Z. Z. Nagy, F. Munier, A. Hierlemann, B. RoskaCongenital Nystagmus Gene FRMD7 Is Necessary for Establishing a Neuronal Circuit Asymmetry for Direction Selectivity“ Neuron 89, 177 (2016). [Link]
B. Source, C. Escobedo, Y. Toyoda, M. P. Stewart, C. J. Cattin, R. Newton, I. Banerjee, A. Stettler, B. Roska, S. Eaton, A. A. Hyman, A. Hierlemann, D. J. MüllerMitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement“ Nat. Commun. 6, 8872 (2015). [Link] [More Information]
M. Fiscella, F. Franke, K. Farrow, J. Muller, B. Roska, R. A. da Silveira, A. Hierlemann “Visual coding with a population of direction-selective neurons“ J. Neurophysiol. 114, 2485-99 (2015). [Link]
A. Adamantidis, S. Arber, J. S. Bains, E. Bamberg, A. Bonci, G. Buzsaki, J. A. Cardin, R. M. Costa, Y. Dan, Y. Goda, A. M. Graybiel, M. Hausser, P. Hegemann, J. R. Huguenard, T. R. Insel, P. H. Janak, D. Johnston, S. A. Josselyn, C. Koch, A. C. Kreitzer, C. Luscher, R. C. Malenka, G. Miesenbock, G. Nagel, B. Roska, M. J. Schnitzer, K. V. Shenoy, I. Soltesz, S. M. Sternson, R. Y. Tsien, G. G. Turrigiano, K. M. Tye, R. I. Wilson “Optogenetics: 10 years after ChR2 in neurons--views from the community“ Nat. Neurosci. 18, 1202-12 (2015). [Link]
A. Wertz, S. Trenholm, K. Yonehara, D. Hillier, Z. Raics, M. Leinweber, G. Szalay, A. Ghanem, G. Keller, B. Rózsa, K. K. Conzelmann, B. RoskaSingle-cell–initiated monosynaptic tracing reveals layer-specific cortical network modules“ Science 349, 70 (2015). [Link] [More Information]
I. Krol, C. P. Alvarez, M. Fiscella, A. Hierlemann, B. Roska, W. Filipowicz “A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture“ Nat. Commun. 6, 7305 (2015). [Link]
J. Krol, B. RoskaRods Feed Cones to Keep them Alive“ Cell 161, 706-08 (2015). [Link]
T. Szikra, S. Trenholm, A. Drinnenberg, J. Jüttner, Z. Raics, K. Farrow, M. Biel, G. Awatramani, D. A. Clark, J. A. Sahel, R. Azeredo da Silveira, B. RoskaRods in daylight act as relay cells for cone-driven horizontal cell–mediated surround inhibition“ Nat. Neurosci. 17, 1728 (2014). [Link]
K. Yonehara, B. RoskaNeuroscience: retinal projectome reveals organizing principles of the visual system“ Curr. Biol. 24, R833-5 (2014). [Link]
T. Cronin, L. H. Vandenberghe, P. Hantz, J. Juttner, A. Reimann, A. E. Kacsó, R. M. Huckfeldt, V. Busskamp, H. Kohler, P. S. Lagali, B. Roska, J. Bennett “Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter“ EMBO Mol. Med. 6, 1175 (2014). [Link]
A. S. Chuong, M. L. Miri, V. Busskamp, G. A. C. Matthews, L. C. Acker, A. T. Sørensen, A. Young, N. C. Klapoetke, M. A. Henninger, S. B. Kodandaramaiah, M. Ogawa, S. B. Ramanlal, R. C. Bandler, B. D. Allen, C. R. Forest, B. Y. Chow, X. Han, Y. Lin, K. M. The, B. Roska, J. A. Cardin, E. S. Boyden “Noninvasive optical inhibition with a red-shifted microbial rhodopsin “ Nat. Neurosci. 17, 1123 (2014). [Link]
V. Busskamp, J. Krol, D. Nelidova, J. Daum, T. Szikra, B. Tsuda, J. Jüttner, K. Farrow, B. Gross Scherf, C. P. Patino Alvarez, C. Genoud, V. Sothilingam, N. Tanimoto, M. Stadler, M. Seeliger, M. Stoffel, W. Filipowicz, B. RoskamiRNAs 182 and 183 Are Necessary to Maintain Adult Cone Photoreceptor Outer Segments and Visual Function“ Neuron 83, 586 (2014). [Link]