Translational Applications Towards Vision Restoration - NCCR MSE

Translational Applications Towards Vision Restoration

The project evaluates the natural course of Stragardt disease in order to develop appropriate clinical endpoints for upcoming trials in Stargardt disease.

STGD is fast progressing degenerative disease of the macula. Understanding disease progression is a key for developing therapeutic approaches, understanding the disease and finding entry points for intervention. In this project, high-resoltuion imaging such as fundus authfluurescence (FAF) and spectral-domain optical coherence tomography (SD-OCT), as well psychophysical examinations (mesopic and scotopic) microperimetry are applied.

Publications

M. Della Volpe Waizel, H. Scholl, M. G. Todorova “Microvascular and Metabolic Alterations in Retinitis Pigmentosa and Stargardt Disease“ Acta Ophthalmol. 2021. [DOI]
M. Reich, M. Dreesbach, D. Boehringer, J. Schottenhamml, E. Gehring, H. Scholl, N. Inglin, H. Agostini, T. Reinhard, W. A. Lagrèze, R. F. Spaide, C. Lange, P. M. Maloca “Negative Vessel Remodeling in Stargardt Disease Quantified with Volume-Rendered Optical Coherence Tomography Angiography“ Retina 2021. [DOI]
O. Zabek, H. Camenzind Zuche, U. Müller, H. Scholl, A. Rickmann, M. della Volpe Waizel “Optical coherence tomography angiography findings in patients undergoing transcorneal electrical stimulation for treating retinitis pigmentosa“ Graefes Arch. Clin. Exp. Ophthalmol. 2020. [DOI]
C. S. Cowan, M. Renner, M. De Gennaro, B. Gross-Scherf, D. Goldblum, Y. Hou, M. Munz, T. M. Rodrigues, J. Krol, T. Szikra, R. Cuttat, A. Waldt, P. Papasaikas, R. Diggelmann, C. P. Patino-Alvarez, P. Galliker, S. E. Spirig, D. Pavlinic, N. Gerber-Hollbach, S. Schuierer, A. Srdanovic, M. Balogh, R. Panero, A. Kusnyerik, A. Szabo, M. B. Stadler, S. Orgül, S. Picelli, P. W. Hasler, A. Hierlemann, H. Scholl, G. Roma, F. Nigsch, B. Roska “Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution“ Cell 2020. [DOI]
M. G. Todorova, H. Scholl, M. della Volpe-Waizell “The impact of macular edema on microvascular and metabolic alterations in retinitis pigmentosa“ Graefes Arch. Clin. Exp. Ophthalmol. 2020. [DOI]
D. Nelidova, R. K. Morikawa, C. S. Cowan, Z. Raics, D. Goldblum, H. Scholl, T. Szikra, A. Szabo, D. Hillier, B. Roska “Restoring light sensitivity using tunable near-infrared sensors“ Science 2020. [DOI]
M. della Volpe-Waizel, H. C. Zuche, U. Müller, A. Rickmann, H. Scholl, M. G. Todorova “Metabolic monitoring of transcorneal electrical stimulation in retinitis pigmentosa“ Graefes Arch. Clin. Exp .Ophthalmol. 2019. [DOI]
J. Jüttner, A. Szabo, B. Gross-Scherf, R. K. Morikawa, S. B. Rompani, P. Hantz, T. Szikra, F. Esposti, C. S. Cowan, A. Bharioke, C. P. Patino-Alvarez, . Keles, A. Kusnyerik, T. Azoulay, D. Hartl, A. R. Krebs, D. Schübeler, R. I. Hajdu, A. Lukats, J. Nemeth, Z. Z. Nagy, R. Wu, L. Xiang, X. Fang, Z. Jin, D. Goldblum, P. W. Hasler, H. Scholl, J. Krol, B. Roska “Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates and humans“ Nat. Neurosci. 2019. [DOI]
R. W. Strauss, X. Kong, A. Ho, A. Jha, S. West, M. Ip, P. S. Bernstein, D. G. Birch, A. V. Cideciyan, M. Michaelides, J. Sahel, J. S. Sunness, E. I. Traboulsi, E. Zrenner, S. Pitetta, D. Jenkins, A. H. Hariri, S. Sadda, H. Scholl “Progression of Stargardt Disease as Determined by Fundus Autofluorescence Over a 12-Month Period: ProgStar Report No. 11“ JAMA Ophthalmol. 2019. [DOI]
A. Ervin, R. W. Strauss, M. I. Ahmed, D. Birch, J. Cheetham, F. L. F. III, M. S. Ip, G. J. Jaffe, M. G. Maguire, E. M. Schönbach, S. R. Sadda, S. K. West, H. Scholl “A Workshop on Measuring the Progression of Atrophy Secondary to Stargardt Disease in the ProgStar Studies: Findings and Lessons Learned“ Transl. Vis. Sci. Technol. 2019, 8(2):16. [DOI]

Project Leader

Hendrik Scholl

Lab

Scholl group @IOB