- NCCR MSE

Molecular Factories Based on Biomolecular-Polymer Assemblies

Engineering Cellular Systems.
Engineering Cellular Systems.
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Publications

S. Hirschi, T. R. Ward, W. P. Meier, D. J. MüllerD. Fotiadis “Synthetic Biology: Bottom-Up Assembly of Molecular Systems“ Chem. Rev. 2022. [DOI]
M. Bina, A. Krywko-Cendrowska, D. Daubian, W. Meier, C. G. Palivan “Multicomponent Copolymer Planar Membranes with Nanoscale Domain Separation“ Nano Lett. 2022. [DOI]
A. Najer, A. Belessiotis-Richards, H. Kim, C. Saunders, F. Fenaroli, C. Adrianus, J. Che, R. L. Tonkin, H. Høgset, S. Lörcher, M. Penna, S. G. Higgins, W. Meier, I. Yarovsky, M. M. Stevens “Block Length-Dependent Protein Fouling on Poly(2-oxazoline)-Based Polymersomes: Influence on Macrophage Association and Circulation Behavior“ Small 2022. [DOI]
S. Di Leone, M. Kyropoulou, J. Köchlin, R. Wehr, W. P. Meier, C. G. Palivan “Tailoring a Solvent-Assisted Method for Solid-Supported Hybrid Lipid–Polymer Membranes“ Langmuir 2022. [DOI]
M. Korpidou, V. Maffeis, I. A. Dinu, C. Schoenenberger, W. P. Meier, C. G. Palivan “Inverting glucuronidation of hymecromone in situ by catalytic nanocompartments“ J. Mater. Chem. B 2022. [DOI]
R. Wehr, E. C. dos Santos, M. S. Muthwill, V. Chimisso, J. Gaitzsch, W. Meier “Fully amorphous atactic and isotactic block copolymers and their self-assembly into nano- and microscopic vesicles“ Polym. Chem. 2021. [DOI]
S. Di Leone, J. Vallapurackal, S. Yorulmaz Avsar, M. Kyropolou, T. R. WardC. G. Palivan, W. Meier “Expanding the Potential of the Solvent-Assisted Method to Create Bio-Interfaces from Amphiphilic Block Copolymers“ Biomacromolecules 2021. [DOI]
M. Kyropoulou, S. Yorulmaz Avsar, C. Schoenenberger, C. G. Palivan, W. P. Meier “From spherical compartments to polymer films: exploiting vesicle fusion to generate solid supported thin polymer membranes“ Nanoscale 2021. [DOI]
V. Chimisso, S. Conti, P. Kong, C. Fodor, W. P. Meier “Metal Cation Responsive Anionic Microgels: Behaviour Towards Biologically Relevant Divalent and Trivalent Ions“ Soft Matter 2021. [DOI]
D. Daubian, A. Fillion, J. Gaitzsch, W. Meier “One-Pot Synthesis of an Amphiphilic ABC Triblock Copolymer PEO-b-PEHOx-b-PEtOz and Its Self-Assembly into Nanoscopic Asymmetric Polymersomes“ Macromolecules 2020. [DOI]
E. C. dos Santos, A. Belluati, D. Necula, D. Scherrer, C. E. Meyer, R. P. Wehr, E. LörtscherC. G. Palivan, W. Meier “Combinatorial Strategy for Studying Biochemical Pathways in Double Emulsion Templated Cell-Sized Compartments“ Adv. Mater. 2020. [DOI]
J. Folini, W. Murad, F. Mehner, W. Meier, J. Gaitzsch “Updating radical ring-opening polymerisation of cyclic ketene acetals from synthesis to degradation“ Eur. Polym. J. 2020. [DOI]
I. A. Dinu, S. S. Saxer, W. P. Meier, U. Pieles, N. Bruns “Stabilizing Enzymes within Polymersomes by Co-Encapsulation of Trehalose“ Biomacromolecules 2020. [DOI]
R. Wehr, J. Gaitzsch, D. Daubian, C. Fodor, W. Meier “Deepening the insight into poly(butylene oxide)-block-poly(glycidol) synthesis and self-assemblies: micelles, worms and vesicles“ RSC Adv. 2020. [DOI]
A. Belluati, S. Thamboo, A. Najer, V. Maffeis, C. von Planta, I. Craciun, C. G. Palivan, W. Meier “Multicompartment Polymer Vesicles with Artificial Organelles for Signal-Triggered Cascade Reactions Including Cytoskeleton Formation“ Adv. Funct. Mater. 2020. [DOI]
E. C. dos Santos, A. Angelini, D. Hürlimann, W. Meier, C. G. Palivan “Giant Polymer Compartments for Confined Reactions“ Chemistry 2020. [DOI]
S. Di Leone, S. Yorulmaz Avsar, A. Belluati, R. Wehr, C. G. Palivan, W. P. Meier “Polymer-Lipid Hybrid Membranes as a Model Platform to Drive Membrane-Cytochrome c Interaction and Peroxidase-like Activity“ J. Phys. Chem. B 2020. [DOI]
A. Krywko-Cendrowska, S. di Leone, M. Bina, S. Yorulmaz-Avsar, C. G. Palivan, W. Meier “Recent Advances in Hybrid Biomimetic Polymer-Based Films: from Assembly to Applications“ Polymers 2020. [DOI]
D. Daubian, J. Gaitzsch, W. Meier “Synthesis and complex self-assembly of amphiphilic block copolymers with a branched hydrophobic poly(2-oxazoline) into multicompartment micelles, pseudo-vesicles and yolk/shell nanoparticles“ Polym. Chem. 2020. [DOI]
S. Rigo, D. Hürlimann, L. Marot, M. Malmsten, W. Meier, C. G. Palivan “Decorating Nanostructured Surfaces with Antimicrobial Peptides to Efficiently Fight Bacteria“ ACS Appl. Bio Mater. 2020. [DOI]
T. Einfalt, M. Garni, D. Witzigmann, S. Sieber, N. Baltisberger, J. Huwyler, W. Meier, C. G. Palivan “Bioinspired Molecular Factories with Architecture and In Vivo Functionalities as Cell Mimics“ Adv. Sci. 2020. [DOI]
A. Belluati, V. Mikhalevich, S. Yorulmaz Avsar, D. Daubian, I. Craciun, M. Chami, W. P. Meier, C. G. Palivan “How do the properties of amphiphilic polymer membranes influence the functional insertion of peptide pores?“ Biomacromolecules 2019. [DOI]
M. Kyropoulou, S. DiLeone, A. Lanzilotto, E. C. Constable, C. E. Housecroft, W. P. Meier, C. G. Palivan “Porphyrin Containing Polymersomes with Enhanced ROS Generation Efficiency: In Vitro Evaluation“ Macromol. Biosci. 2019. [DOI]
J. Folini, C. Huang, J. C. Anderson, W. P. Meier, J. Gaitzsch “Novel monomers in radical ring-opening polymerisation for biodegradable and pH responsive nanoparticles“ Polym. Chem. 2019. [DOI]
V. Chimisso, C. Fodor, W. Meier “Effect of Divalent Cation on Swelling Behavior of Anionic Microgels: Quantification and Dynamics of Ion Uptake and Release“ Langmuir 2019. [DOI]
V. Chimisso, V. Maffeis, D. Hürlimann, C. G. Palivan, W. Meier “Self-Assembled Polymeric Membranes and Nanoassemblies on Surfaces: Preparation, Characterization, and Current Applications“ Macromol. Biosci. 2019. [DOI]
S. Thamboo, A. Najer, A. Belluati, C. von Planta, D. Wu, I. Craciun, W. Meier, C. G. Palivan “Mimicking Cellular Signaling Pathways within Synthetic Multicompartment Vesicles with Triggered Enzyme Activity and Induced Ion Channel Recruitment“ Adv. Funct. Mater. 2019. [DOI]
J. Gaitzsch, S. Hirschi, S. Freimann, D. Fotiadis, W. Meier “Directed Insertion of Light-Activated Proteorhodopsin into Asymmetric Polymersomes from an ABC Block Copolymer“ Nano Lett. 2019. [DOI]
E. V. Konishcheva, D. Daubian, S. Rigo, W. P. Meier “Probing membrane asymmetry of ABC polymersomes“ Chem. Commun. 2019. [DOI]
S. Yorulmaz Avsar, M. Kyropoulou, S. Di Leone, C. Schoenenberger, W. P. Meier, C. G. Palivan “Biomolecules Turn Self-Assembling Amphiphilic Block Co-polymer Platforms Into Biomimetic Interfaces“ Front. Chem. 2019, 6:645. [DOI]
A. Angelini, C. Fodor, W. Yave, L. Leva, A. Car, W. Meier “pH-Triggered Membrane in Pervaporation Process“ ACS Omega 2018. [DOI]
M. Garni, R. Wehr, S. Yorulmaz Avsar, C. John, C. G. Palivan, W. Meier “Polymer membranes as templates for bio-applications ranging from artificial cells to active surfaces“ Eur. Polym. J. 2018. [DOI]
E. V. Konishcheva, U. E. Zhumaev, W. P. Meier “Self-Assembly of PEO-b-PCL-b-PMOXA Binary Mixtures“ Macromolecules 2018. [DOI]
S. Rigo, G. Gunkel-Grabole, W. Meier, C. G. Palivan “Surfaces with Dual Functionality through Specific Coimmobilization of Self-Assembled Polymeric Nanostructures“ 2018. [DOI]
M. E. Idrissi, C. E. Meyer, L. Zartner, W. Meier “Nanosensors based on polymer vesicles and planar membranes: a short review“ J. Nanobiotechnol. 2018. [DOI]
M. Garni, T. Einfalt, R. Goers, C. G. Palivan, W. P. Meier “Live follow-up of enzymatic reactions inside the cavities of synthetic giant unilamellar vesicles (GUVs) equipped with membrane proteins mimicking cell architecture“ ACS Synth. Biol. 2018. [DOI]
G. Gunkel-Grabole, W. Meier “Biomimetic Polymer Architectures“ Chimia 2018, 72:548-548. [DOI]
C. L. Draghici, V. Mikhalevich, G. Gunkel-Grabole, J. Kowal, W. P. Meier, C. G. Palivan “Biomimetic planar Polymer Membranes decorated with Enzymes as Functional Surfaces“ Langmuir 2018. [DOI]
R. Goers, J. Thoma, N. Ritzmann, A. Di Silvestro, C. Alter, G. Gunkel-Grabole, D. FotiadisD. J. Müller, W. Meier “Optimized reconstitution of membrane proteins into synthetic membranes“ Commun. Chem. 2018. [DOI]
A. Najer, C. G. Palivan, H. Beck, W. Meier “Challenges in Malaria Management and a Glimpse at Some Nanotechnological Approaches“ Infectious Diseases and Nanomedicine III 2018. [DOI]
J. Gaitzsch, P. C. Welsch, J. Folini, C. Schoenenberger, J. C. Anderson, W. Meier “Revisiting Monomer Synthesis and Radical Ring Opening Polymerization of Dimethylated MDO Towards Biodegradable Nanoparticles for Enzymes“ Eur. Polym. J. 2018. [DOI]
E. Konishcheva, D. Daubian, J. Gaitzsch, W. Meier “Synthesis of Linear ABC Triblock Copolymers and Their Self-Assembly in Solution“ Helv. Chim. Acta 2018. [DOI]
A. Lanzilotto, M. Kyropoulou, E. C. Constable, C. E. Housecroft, W. P. Meier, C. G. Palivan “Porphyrin-polymer nanocompartments: singlet oxygen generation and antimicrobial activity“ 2017. [DOI]
J. Gaitzsch, L. Messager, E. Morecroft, W. Meier “Vesicles in Multiple Shapes: Fine-Tuning Polymersomes’ Shape and Stability by Setting Membrane Hydrophobicity“ Polymers 2017, 9(10):483. [DOI]
E. V. Konishcheva, U. E. Zhumaev, M. Kratt, V. Oehri, W. Meier “Complex Self-Assembly Behavior of Bis-hydrophilic PEO-b-PCL-b-PMOXA Triblock Copolymers in Aqueous Solution“ Macromolecules 2017. [DOI]
C. Edlinger, T. Einfalt, M. Spulber, A. Car, W. Meier, C. G. Palivan “Biomimetic Strategy To Reversibly Trigger Functionality of Catalytic Nanocompartments by the Insertion of pH-Responsive Biovalves“ Nano Lett. 2017. [DOI]
V. Mikhalevich, I. Craciun, M. Kyropoulou, C. G. Palivan, W. Meier “Amphiphilic peptide self-assembly: Expansion to hybrid materials“ Biomacromolecules 2017. [DOI]
G. Gunkel-Grabole, C. G. Palivan, W. Meier “Nanostructured Surfaces through Immobilization of Self-Assembled Polymer Architectures Using Thiol–Ene Chemistry“ Macromol. Mater. Eng. 2017, 302:1600363. [DOI]
I. Craciun, G. Gunkel-Grabole, A. Belluati, C. G. Palivan, W. Meier “Expanding the potential of MRI contrast agents through multifunctional polymeric nanocarriers“ Nanomedicine 2017, 12:811-17. [DOI]
S. MatileC. G. Palivan “Strain-Promoted Thiol-Mediated Cellular Uptake of Giant Substrates: Liposomes and Polymersomes“ Angew. Chem. Int. Ed. 2017, 56:2947-50. [DOI]
S. Lörcher, W. Meier “Cosolvent fractionation of PMOXA-b-PDMS-b-PMOXA: Bulk separation of triblocks from multiblocks“ Eur. Polym. J. 2017. [DOI]
P. Baumann, M. Spulber, O. Fischer, A. Car, W. Meier “Investigation of Horseradish Peroxidase Kinetics in an “Organelle-Like” Environment“ Small 2017, 13:1603943. [DOI] [More Information]
E. V. Konishcheva, U. E. Zhumaev, W. P. Meier “PEO-b-PCL-b-PMOXA Triblock Copolymers: From Synthesis to Microscale Polymersomes with Asymmetric Membrane“ Macromolecules 2017. [DOI]
J. Liu, V. Postupalenko, S. Lörcher, D. Wu, M. Chami, W. Meier, C. G. Palivan “DNA-Mediated Self-Organization of Polymeric Nanocompartments Leads to Interconnected Artificial Organelles“ Nano Lett. 2016:DOI: 10.1021/acs.nanolett.6b03430. [DOI] [More Information]
D. Vasquez, T. Einfalt, W. Meier, C. G. Palivan “Asymmetric Triblock Copolymer Nanocarriers for Controlled Localization and pH-Sensitive Release of Proteins“ Langmuir 2016, 32:10235-43. [DOI]
S. J. Sigg, F. Santini, A. Najer, P. U. Richard, W. P. Meier, C. G. Palivan “Nanoparticle-based highly sensitive MRI contrast agents with enhanced relaxivity in reductive milieu“ Chem. Commun. 2016, 52:9937-40. [DOI]
D. Harder, S. Hirschi, Z. Ucurum, R. Goers, W. Meier, D. J. MüllerD. Fotiadis “Engineering a Chemical Switch into the Light-driven Proton Pump Proteorhodopsin by Cysteine Mutagenesis and Thiol Modification“ Angew. Chem. Int. Ed.  2016, 55:8846. [DOI]
A. Najer, D. Wu, M. G. Nussbaumer, G. Schwertz, A. Schwab, M. C. Witschel, A. Schäfer, F. Diederich, M. Rottmann, C. G. Palivan, H. Beck, W. Meier “An amphiphilic graft copolymer-based nanoparticle platform for reduction-responsive anticancer and antimalarial drug delivery“ Nanoscale 2016:DOI: 10.1039/C6NR04290B. [DOI]
S. HirschiM. Stauffer, D. Harder, D. J. Müller, W. Meier, D. Fotiadis “Engineering and Assembly of Protein Modules into Functional Molecular Systems“ Chimia 2016, 6:398. [DOI]
Y. Cotelle, N. Chuard, S. Lascano, V. Lebrun, R. Wehlauch, N. Bohni, S. Lörcher, V. Postupalenko, S. Reddy, W. Meier, C. G. Palivan, K. Gademann, T. R. WardS. Matile “Interfacing Functional Systems“ Chimia 2016, 6:418. [DOI]
C. E. HousecroftC. G. Palivan, K. Gademann, W. Meier, M. Calame, V. Mikhalevich, X. Zhang, E. Piel, M. Szponarski, A. Wiesler, A. Lanzilotto, E. C. Constable, A. Fanget, R. Stoop “‘Active surfaces’ as Possible Functional Systems in Detection and Chemical (Bio) Reactivity“ Chimia 2016, 6:402. [DOI]
M. Garni, T. Einfalt, M. Lomora, A. Car, W. Meier, C. G. Palivan “Artificial Organelles: Reactions inside Protein–Polymer Supramolecular Assemblies“ Chimia 2016, 6:424. [DOI]
V. Mikhalevich, C. Zelmer, A. Car, C. G. Palivan, W. Meier “Bio-inspired Polymer Membranes“ Bio-inspired Polymers 2016, 22:221-58. [DOI]
I. A. Dinu, J. T. Duskey, A. Car, C. G. Palivan, W. Meier “Engineered non-toxic cationic nanocarriers with photo-triggered slow-release properties“ Polym. Chem. 2016, 7:3451. [DOI]
A. Najer, S. Thamboo, C. G. Palivan, H. Beck, W. Meier “Giant Host Red Blood Cell Membrane Mimicking Polymersomes Bind Parasite Proteins and Malaria Parasites“ Chimia 2016, 4:288. [DOI]
S. J. Sigg, V. Postupalenko, J. T. Duskey, C. G. Palivan, W. Meier “Stimuli-Responsive Codelivery of Oligonucleotides and Drugs by Self-Assembled Peptide Nanoparticles“ Biomacromolecules 2016, 17:935-45. [DOI]
X. Zhang, M. Lomora, T. Einfalt, W. Meier, N. Klein, D. Schneider, C. G. Palivan “Active surfaces engineered by immobilizing protein-polymer nanoreactors for selectively detecting sugar alcohols“ Biomaterials 2016, 89:79. [DOI]
G. Gunkel-Grabole, A. Car, V. V. Naik, L. Marot, G. Ferk, C. G. Palivan, W. Meier “PEG Brushes on Porous, PDMS-Coated Surfaces and Their Interaction with Carbon Dioxide“ Macromol. Chem. Phys. 2016, 217:966. [DOI]
C. G. Palivan, R. Goers, A. Najer, X. Zhang, A. Car, W. Meier “Bioinspired polymer vesicles and membranes for biological and medical applications“ Chem. Soc. Rev. 2015, 45:377. [DOI]
A. Najer, S. Thamboo, J. T. Duskey, W. Meier, C. G. Palivan “Analysis of Molecular Parameters Determining the Antimalarial Activity of Polymer-Based Nanomimics“ Macromol. Rapid Commun. 2015, 36:1923. [DOI]
J. Liu, V. Postupalenko, J. T. Duskey, C. G. Palivan, W. Meier, V. Mikhalevich “pH-Triggered Reversible Multiple Protein-Polymer Conjugation Based on Molecular Recognition“ J. Chem. Phys. B. 2015, 119:12066. [DOI]
G. Tsiavaliaris, F. Itel, K. Hedfalk, S. Al-Samir, W. P. Meier, G. Gros, V. Endeward “Low CO2 permeability of cholesterol-containing liposomes detected by stopped-flow fluorescence spectroscopy“ FASEB J. 2015, 29:1780. [DOI]
F. Itel, A. Najer, C. G. Palivan, W. Meier “Dynamics of Membrane Proteins within Synthetic Polymer Membranes with Large Hydrophobic Mismatch“ Nano Lett. 2015, 15:3871. [DOI] [More Information] [Artikel in ChimieXtra]
J. Kowal, D. Wu, V. MikhalevichC. G. Palivan, W. Meier “Hybrid Polymer–Lipid Films as Platforms for Directed Membrane Protein Insertion“ Langmuir 2015, 31:4868. [DOI]
T. Schuster, M. Nussbaumer, P. Baumann, N. Bruns, W. Meier, A. Car “Polymeric particulates for subunit vaccine delivery“ Subunit Vaccine Delivery 2015:181-201. [DOI]
G. Gunkel-Grabole, S. Sigg, M. Lomora, S. Lörcher, C. G. Palivan “Polymeric 3D nano-architectures for transport and delivery of therapeutically relevant biomacromolecules“ Biomater. Sci. 2015, 2:25. [DOI]
A. Najer, D. Wu, A. Bieri, F. Brand, C. G. Palivan, H. P. Beck, W. Meier “Nanomimics of Host Cell Membranes Block Invasion and Expose Invasive Malaria Parasites“ ACS Nano 2014, 8:12560. [DOI] [More Information]
F. Itel, M. Chami, A. Najer, S. Lörcher, D. Wu, I. A. Dinu “Molecular organization and dynamics in polymersome membranes: A lateral diffusion study“ Macromolecules 2014, 47:7588. [DOI]
D. Wu, M. Spulber, F. Itel, M. Chami, T. Pfohl, C. G. Palivan, W. Meier “Effect of Molecular Parameters on the Architecture and Membrane Properties of 3D Assemblies of Amphiphilic Copolymers“ Macromolecules 2014, 47:5060-69. [DOI]
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