Molecular Systems Engineering

A paradigm shift focusing on molecular factories, cellular systems and the improvement of health.

2024 International Conference on Molecular Systems Engineering

2-4 September 2024, Basel

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Botond Roska wins the Wolf Prize 2024

Botond Roska, Project Leader at NCCR MSE and Professor at the University of Basel and Director of the Institute of Molecular and Clinical Ophthalmology Basel (IOB), won the Wolf Prize 2024 in the field of medicine.
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Microbial cell factories for cycloalkene synthesis

© Nature Synthesis

Researchers from the Ward group describe in Nature Synthesis a whole-cell hybrid biocatalytic cascade comprising a natural decarboxylase and an artificial ‘metathase’ enzyme that are targeted to different cellular locations, for the production of cycloalkenes from fatty diacids. This is a major step forward towards microbial cell factories augmented with abiological chemistry.
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An electrical switch to control chemical reactions

© Stefan Matile

New pharmaceuticals, cleaner fuels, biodegradable plastics: in order to meet society’s needs, chemists have to develop new synthesis methods to obtain new products that do not exist in their natural state. The Matile group, in collaboration with Cardiff University, has discovered how to use an external electric field to control and accelerate a chemical reaction, like a ‘‘switch’’. This work could have a considerable impact on the development of new molecules, enabling not only more environmentally friendly synthesis, but also very simple external control of a chemical reaction.
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Genetically modifying individual cells in animals

Symbol image created with Midjourney. Visualisations: ETH Zurich

Researchers from the Platt group have developed a method that lets them genetically modify each cell differently in animals. This allows them to study in a single experiment what used to require many animal experiments. Using the new method, the researchers have discovered genes that are relevant for a severe rare genetic disorder.
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Barbara Treutlein receives renowned Cloëtta Jubilee Prize

Barbara Treutlein, NCCR MSE Project Leader and Head of the Quantitative Developmental Biology Lab at the D-​BSSE, has been awarded the Cloëtta Jubilee Prize for her outstanding achievements in biomedical and developmental biology research.
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Cells with an ear for music release insulin

Image: Keystone SDA / Science Photo Library. Montage: Katja Schubert

"We will rock you": NCCR MSE researchers from the Fussenegger group are developing a gene switch that triggers insulin release in designer cells by playing certain rock and pop songs. The insulin-​producing designer cells were equipped with an ion channel of a bacterium that reacts to mechanical stimuli like sound waves.
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In memory of Wolfgang Meier

Image: Macromolecular Rapid Communications

A special issue commemorating Wolfgang Meier, who had significant contributions in the fields of amphiphilic copolymer syntheses and their hierarchical self-assembly, block copolymer vesicles (so-called polymersomes), and hybrid membranes has been published jointly by Macromolecular Rapid Communications and Macromolecular Bioscience.
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Ethical considerations of human stem cell-derived embryo models

A day 8 stem cell-derived mouse embryo with developing brain and heart regions.
Image credit: Kasey Lau for the Zernicka-Goetz laboratory

Human pluripotent stem cells can be used to derive in vitro models recapitulating post-implantation human embryos. While useful for research purposes, such integrated embryo models raise ethical issues that need to be addressed to facilitate ethically appropriate policies and regulations that permit scientific ingenuity and medical progress. A perspective written by Alessandro Blasimme from the Vayena group.
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Under control to the very end – how our cells kill themselves

Image: Biozentrum, University Basel

Every day, millions of cells die in our body. Other than generally assumed, cells do not simply burst at the end of their lives but rather, a specific protein serves as a breaking point for cell membrane rupture. As part of a larger initiative,  researchers from the Müller group have now been able to elucidate the exact mechanism at the atomic level. They have published their results in the journal Nature.
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Detailed image of the human retina

Image: Wahle et al. Nature Biotechnology 2023

Researchers from Basel and Zurich, including the NCCR MSE groups of Treutlein, Roska and Scholl are creating a high-​resolution atlas that depicts the development of the human retina. One technique they use is a new method that allows them to visualise more than 50 proteins simultaneously. The results have been published in the journal Nature Biotechnology.
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New embryonic brain circuit discovered

Image: IOB

Researchers in the Roska group have identified a new brain circuit in mouse embryos that develops at an unexpectedly early stage. Their findings may provide new insights into circuit abnormalities in autism. The results have been published in the journal Cell.
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Meet our Science Ambassadors to the Locarno Film Festival 2024

NCCR MSE again sends a group of 5 young researchers to the Locarno Film Festival to work and connect at the intersection of art and science. This will be a great chance for pur team to connect with hundreds of young international audio-visual artists and to enhance their proficiency in science communication. Meet our team of Science Ambassadors from ETH Zurich, Basel University and Heidelberg University.
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10 Years in 5 Minutes

2024 marks the 10th anniversary of NCCR MSE. In our podcast series "10 Years in 5 Minutes" (10Y5M), researchers, friends and associates look back on a decade of groundbreaking research, recalling encounters and scientific achievements within this outstanding scientific consortium.
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Come to Rome!

The 2nd International Conference on Ethics of Engineering Life (ICEEL) invites young researchers to come to Rome and discuss with leading experts the ethical challenges of Engineering Life. A limited number of travel grants covering travel and accommodation costs are available. Apply now!
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Are you interested to Bridge Horizons?

NCCR MSE’s exciting collaboration with the Locarno Film Festival has inspired all stakeholders to take this initiative to the next level: “Bridging Horizons - Art and Science's Creative Collision” is our latest art-science exchange program, which will be launched in March 2024.
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"Engineering Life" symposium at the Swiss Embassy in London

Together with the Embassy of Switzerland in the UK our NCCR MSE organized a Symposium about "Engineering Life - State of the Art and Ethical Challenges“ - held on Tuesday, 20 June 2023, at the Embassy in London.
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ICEEL Ethics Statement

New biotechnologies are becoming more viable and have the potential to affect the lives of millions of people around the world. Issues emerging from their development may be considered under two main perspectives: the need i) for researchers and, more broadly, all the stakeholders involved in the translation from the lab to the real world to be aware of the ethical, legal, and political implications; and ii) to foster dialogue with the public on these implications. In this regard, it is crucial to inform citizens properly about these new technologies and their ethical implications. Equally important, all stakeholders must take into consideration citizens’ worries, doubts, and real needs to foster clarity and trust between them and the scientific community with respect to these delicate scientific developments.
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AoM Podcast: Roald Hoffmann

Chemistry Nobel Laureate Roald Hoffmann visited Switzerland in May 2022 giving a series of scientific lectures, and also presenting the world premiere of "Alchemy", a melodrama written by him together with Austrian composer Oliver Peter Graber.

In this podcast, Roald Hoffmann reveals some very personal episodes from his life which began in 1937 in his (then Polish) birthplace Złoczów and after World War II led to emigration to the United States.
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Ralf's corner: More experts, please!

According to my 600 Euro smart watch I passed away three days ago somewhere between 1:51 AM and 3:20 AM. During that time span - I was sound asleep and do not recall any exciting dreams - my heartbeat rate (bpm) apparently exceeded 220 permanently and reached an all-time high of 300 beats per minute, prompting my online health data collection app to celebrate my passing by sending me an Email with a bouquet of flowers emoji: "Congratulations, Ralf! You have reached a milestone! 💐".
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To celebrate the 50th anniversary of women obtaining the right to vote in Switzerland, NCCR MSE joined forces with all the other NCCRs to introduce you to some of the women working in Swiss research institutes.

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Online professional coaching

NCCR MSE is offering online professional coaching for free to all NCCR members during the COVID-19 pandemic. Just contact Hala Helmy, who is a professional BSO certified coach and supervisor with over 10 years of work experience.

The Electrical Origins of Life

Prof. Nick Lane uses life as a guide to its own origins. Modern cells use electrical charges on membranes to drive their metabolism, which in turn makes the building blocks of genes and proteins.

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Paving the way towards more women in leading academic positions

Why do we lose female talents in top positions in the academia? What can we do to avoid this loss? What are the possible solutions and what are the advice of female group leaders? Achieving gender Equality and diversity in the Natural Sciences: The leaky pipeline phenomenon summarized in a new short video!

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Alchemy - World première

On May 6, 2022, NCCR MSE together with an audience of 100 guests witnessed an extraordinary world première of an opera written by Chemistry Nobel Laureate Roald Hoffmann (libretto) and Austrian composer Oliver Peter Graber.

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Scientific Excellence and Equality – a Contradiction?

Prof. Tom Welton discusses current academic, structural and institutional challenges universities face today to promote equality while assuring that a high level of scientific excellence is maintained.

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Locarno Talks la Mobiliare

On August 16, 2019 NCCR MSE staged one of the three "Locarno Talks la Mobiliare" and discussed "The ethical challenges of engineering life and the effects on human identity".

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Lab Concerto

Our public Lab Concerto series premiered in 2019 in the chemistry labs at the University of Basel. The argovia philharmonic classical quartett played works by Händel, Britten, Tscherepnin, Dukas a.o. to an audience which had arrived from all over Switzerland. In between, our young researchers Alina Stein and Jaicy Vallapurackal showed some exciting lab experiments which helped our audience to better understand the research goals of the NCCR MSE.

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Maestro Method

"Maestro Method" is an out of the lab learning tool for our young as well as our experienced scientists. The idea behind it is that by gaining insight into work processes and methodological approaches implemented successfully by non-scientists we may enhance and improve our own professional skills.

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SRF Interview with Ralf Stutzki

Ralf Stutzki, Head Ethics, on scientific misconduct and integrity in research (in German).

SRF Interview with Benjamin Gaub

Watch the interview with NCCR MSE fellow Benjamin Gaub from the Müller group talking about vision restoration in the SRF 1 show gesundheitheute.

Sound of Molecules – I. fiddle (with)

This audio-visual production represents a milestone in the on-going cooperation between NCCR MSE and argovia philharmonic and a most unusual communication tool meant to stimulate the societal debate about the ethical challenges of synthetic biology.

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Lynn Hershman Leeson visits the NCCR MSE

American artist and filmmaker Lynn Hershman Leeson has long studied the relationship between technological innovation and human identity. For her latest project she visited the NCCR MSE on October 27 to discuss art and its role in bridging the gap between science and the public.

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Art of Molecule

Take a look at the projects exploring new horizons at the interface between science and art.