Botond Roska - NCCR MSE

Botond Roska

Friedrich Miescher Institute

Project Leader


Winner of the 2016 Cogan Award

Botond Roska, senior group leader at the FMI and project-leader for the NCCR Molecular Systems Engineering, is a renowned expert in the structure and function of retinal circuits in health and disease. His work has contributed in both a fundamental and highly original manner to our understanding of the function of retinal circuits. In addition, he has used his knowledge of retinal processing and the newly available optogenetic tools to reactivate retinal function, at least partially, in mouse models of blinding retinal diseases. Together with scientist from around the world, but particularly the Vision Institute in Paris, he currently tries to bring this method of vision restoration to patients with retinitis pigmentosa, and other late-onset adult blindness diseases.

The 2016 Cogan Award from the Association of Research in Vision and Ophthalmology now recognizes and highlights these outstanding contributions to the field. With this he joins Ted Drya and Connie Cepko, two thought leaders in the field, who have earlier received this award as well.


A. Bharioke, M. Munz, A. Brignall, G. Kosche, M. F. Eizinger, N. Ledergerber, D. Hillier, B. Gross-Scherf, K. Conzelmann, E. Macé, B. Roska “General anesthesia globally synchronizes activity selectively in layer 5 cortical pyramidal neurons“ Neuron 2022. [DOI]
C. Brunner, M. Grillet, A. Urban, B. Roska, G. Montaldo, E. Macé “Whole-brain functional ultrasound imaging in awake head-fixed mice“ Nat. Protoc. 2021. [DOI]
J. Sahel, E. Boulanger-Scemama, C. Pagot, A. Arleo, F. Galluppi, J. N. Martel, S. D. Esposti, A. Delaux, J. de Saint Aubert, C. de Montleau, E. Gutman, I. Audo, J. Duebel, S. Picaud, D. Dalkara, L. Blouin, M. Taiel, B. Roska “Partial recovery of visual function in a blind patient after optogenetic therapy“ Nat. Med. 2021. [DOI]
C. S. Cowan, M. Renner, M. De Gennaro, B. Gross-Scherf, D. Goldblum, Y. Hou, M. Munz, T. M. Rodrigues, J. Krol, T. Szikra, R. Cuttat, A. Waldt, P. Papasaikas, R. Diggelmann, C. P. Patino-Alvarez, P. Galliker, S. E. Spirig, D. Pavlinic, N. Gerber-Hollbach, S. Schuierer, A. Srdanovic, M. Balogh, R. Panero, A. Kusnyerik, A. Szabo, M. B. Stadler, S. Orgül, S. Picelli, P. W. Hasler, A. Hierlemann, H. Scholl, G. Roma, F. Nigsch, B. Roska “Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution“ Cell 2020. [DOI]
D. Nelidova, R. K. Morikawa, C. S. Cowan, Z. Raics, D. Goldblum, H. Scholl, T. Szikra, A. Szabo, D. Hillier, B. Roska “Restoring light sensitivity using tunable near-infrared sensors“ Science 2020. [DOI]
B. M. Gaub, K. C. Kasuba, E. Mace, T. Strittmatter, P. R. Laskowski, S. A. Geissler, A. Hierlemann, M. FusseneggerB. RoskaD. J. Müller “Neurons differentiate magnitude and location of mechanical stimuli“ Proc. Natl. Acad. Sci. U.S.A. 2019. [DOI]
R. Schubert, S. Herzog, S. Trenholm, B. RoskaD. J. Müller “Magnetically guided virus stamping for the targeted infection of single cells or groups of cells“ Nat. Protoc. 2019. [DOI]
J. Jüttner, A. Szabo, B. Gross-Scherf, R. K. Morikawa, S. B. Rompani, P. Hantz, T. Szikra, F. Esposti, C. S. Cowan, A. Bharioke, C. P. Patino-Alvarez, . Keles, A. Kusnyerik, T. Azoulay, D. Hartl, A. R. Krebs, D. Schübeler, R. I. Hajdu, A. Lukats, J. Nemeth, Z. Z. Nagy, R. Wu, L. Xiang, X. Fang, Z. Jin, D. Goldblum, P. W. Hasler, H. Scholl, J. Krol, B. Roska “Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates and humans“ Nat. Neurosci. 2019. [DOI]
M. della Volpe-Waizel, G. L. Traber, P. Maloca, M. Zinkernagel, U. Schmidt-Erfurth, G. Rubin, B. Roska, T. Otto, R. G. Weleber, H. Scholl “New Technologies for Outcome Measures in Retinal Disease: Review from the European Vision Institute Special Interest Focus Group“ Ophthalmic Res. 2019. [DOI]
B. Roska “The First Steps in Vision: Cell Types, Circuits, and Repair“ EMBO Mol. Med. 2019
E. Macé, G. Montaldo, S. Trenholm, C. Cowan, A. Brignall, A. Urban, B. Roska “Whole-Brain Functional Ultrasound Imaging Reveals Brain Modules for Visuomotor Integration“ Neuron 2018, 100(5):1241-1251.e7. [DOI]
A. Drinnenberg, F. Franke, R. K. Morikawa, J. Jüttner, D. Hillier, P. Hantz, A. Hierlemann, R. Azeredo da Silveira, B. Roska “How Diverse Retinal Functions Arise from Feedback at the First Visual Synapse“ Neuron 2018. [DOI]
R. Schubert, S. Trenholm, K. Balint, G. Kosche, C. S. Cowan, M. A. Mohr, M. Munz, D. Martinez-Martin, G. Fläschner, R. Newton, J. Krol, B. G. Scherf, K. Yonehara, A. Wertz, A. Ponti, A. Ghanem, D. Hillier, K. Conzelmann, D. J. MüllerB. Roska “Virus stamping for targeted single-cell infection in vitro and in vivo“ Nat. Biotechnol. 2017. [DOI]
J. M. Daum, O. Keles, S. J. B. Holwerda, H. Kohler, F. M. Rijli, M. Stadler, B. Roska “The formation of the light-sensing compartment of cone photoreceptors coincides with a transcriptional switch“ eLife 2017, 6:e31437. [DOI]
D. Hillier, M. Fiscella, A. Drinnenberg, S. Trenholm, S. B. Rompani, Z. Raics, G. Katona, J. Juettner, A. Hierlemann, B. Rozsa, B. Roska “Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex“ Nat. Neurosci. 2017. [DOI]
D. Alsteens, R. Newton, R. Schubert, D. Martinez-Martin, M. Delguste, B. RoskaD. J. Müller “Nanomechanical mapping of first binding steps of a virus to animal cells“ Nat. Nanotechnol. 2016:DOI:10.1038/nnano.2016.228. [DOI]
K. Yonehara1, M. Fiscella, A. Drinnenberg, F. Esposti, S. Trenholm, J. Krol, F. Franke, C. Gross Scherf, A. Kusnyerik, J. Müller, A. Szabo, J. Jüttner, F. Cordoba, A. P. Reddy, J. Németh, Z. Z. Nagy, F. Munier, A. Hierlemann, B. Roska “Congenital Nystagmus Gene FRMD7 Is Necessary for Establishing a Neuronal Circuit Asymmetry for Direction Selectivity“ Neuron 2016, 89:177. [DOI]
B. Source, C. Escobedo, Y. Toyoda, M. P. Stewart, C. J. Cattin, R. Newton, I. Banerjee, A. Stettler, B. Roska, S. Eaton, A. A. Hyman, A. Hierlemann, D. J. Müller “Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement“ Nat. Commun. 2015, 6:8872. [DOI] [More Information]
M. Fiscella, F. Franke, K. Farrow, J. Muller, B. Roska, R. A. da Silveira, A. Hierlemann “Visual coding with a population of direction-selective neurons“ J. Neurophysiol. 2015, 114:2485-99. [DOI]
A. Adamantidis, S. Arber, J. S. Bains, E. Bamberg, A. Bonci, G. Buzsaki, J. A. Cardin, R. M. Costa, Y. Dan, Y. Goda, A. M. Graybiel, M. Hausser, P. Hegemann, J. R. Huguenard, T. R. Insel, P. H. Janak, D. Johnston, S. A. Josselyn, C. Koch, A. C. Kreitzer, C. Luscher, R. C. Malenka, G. Miesenbock, G. Nagel, B. Roska, M. J. Schnitzer, K. V. Shenoy, I. Soltesz, S. M. Sternson, R. Y. Tsien, G. G. Turrigiano, K. M. Tye, R. I. Wilson “Optogenetics: 10 years after ChR2 in neurons--views from the community“ Nat. Neurosci. 2015, 18:1202-12. [DOI]
A. Wertz, S. Trenholm, K. Yonehara, D. Hillier, Z. Raics, M. Leinweber, G. Szalay, A. Ghanem, G. Keller, B. Rózsa, K. K. Conzelmann, B. Roska “Single-cell–initiated monosynaptic tracing reveals layer-specific cortical network modules“ Science 2015, 349:70. [DOI] [More Information]
I. Krol, C. P. Alvarez, M. Fiscella, A. Hierlemann, B. Roska, W. Filipowicz “A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture“ Nat. Commun. 2015, 6:7305. [DOI]
J. Krol, B. Roska “Rods Feed Cones to Keep them Alive“ Cell 2015, 161:706-08. [DOI]
T. Szikra, S. Trenholm, A. Drinnenberg, J. Jüttner, Z. Raics, K. Farrow, M. Biel, G. Awatramani, D. A. Clark, J. A. Sahel, R. Azeredo da Silveira, B. Roska “Rods in daylight act as relay cells for cone-driven horizontal cell–mediated surround inhibition“ Nat. Neurosci. 2014, 17:1728. [DOI]
K. Yonehara, B. Roska “Neuroscience: retinal projectome reveals organizing principles of the visual system“ Curr. Biol. 2014, 24:R833-5. [DOI]
T. Cronin, L. H. Vandenberghe, P. Hantz, J. Juttner, A. Reimann, A. E. Kacsó, R. M. Huckfeldt, V. Busskamp, H. Kohler, P. S. Lagali, B. Roska, J. Bennett “Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter“ EMBO Mol. Med. 2014, 6:1175. [DOI]
A. S. Chuong, M. L. Miri, V. Busskamp, G. A. C. Matthews, L. C. Acker, A. T. Sørensen, A. Young, N. C. Klapoetke, M. A. Henninger, S. B. Kodandaramaiah, M. Ogawa, S. B. Ramanlal, R. C. Bandler, B. D. Allen, C. R. Forest, B. Y. Chow, X. Han, Y. Lin, K. M. The, B. Roska, J. A. Cardin, E. S. Boyden “Noninvasive optical inhibition with a red-shifted microbial rhodopsin “ Nat. Neurosci. 2014, 17:1123. [DOI]
V. Busskamp, J. Krol, D. Nelidova, J. Daum, T. Szikra, B. Tsuda, J. Jüttner, K. Farrow, B. Gross Scherf, C. P. Patino Alvarez, C. Genoud, V. Sothilingam, N. Tanimoto, M. Stadler, M. Seeliger, M. Stoffel, W. Filipowicz, B. Roska “miRNAs 182 and 183 Are Necessary to Maintain Adult Cone Photoreceptor Outer Segments and Visual Function“ Neuron 2014, 83:586. [DOI]