Wolfgang Meier - NCCR MSE

Wolfgang Meier

Department of Chemistry, University of Basel

Work Package Leader WP2: Bioinspired Molecular Factories

Project Leader


Prof. Dr. Wolfgang Meier is full professor of physical chemistry at the University of Basel since 2003. He was Department chair from 2008-2011.

His further activities include:

  • Member of the scientific executive board of SystemsX.
  • Vice-director of the Swiss Nanoscience Institute.
  • He acts on the editorial board of Nanomedicine, Polymers, Journal of Biomaterials and Nanobiotechnology, and Biomaterials Science.
  • He is the author of eighty publications and eight patents since 2008.

Together with Daniel Müller (ETH Zürich), Wolfgang Meier launched in 2014 the Swiss National Competence Centre of Research (NCCR) Molecular Systems Engineering in Basel.


J. Gaitzsch, S. Hirschi, S. Freimann, D. FotiadisW. Meier “Directed Insertion of Light-Activated Proteorhodopsin into Asymmetric Polymersomes from an ABC Block Copolymer“ Nano Lett. 2019. [DOI]
E. V. Konishcheva, D. Daubian, S. Rigo, W. Meier “Probing membrane asymmetry of ABC polymersomes“ Chem. Commun. 2019. [DOI]
S. Yorulmaz Avsar, M. Kyropoulou, S. Di Leone, C. Schoenenberger, W. MeierC. G. Palivan “Biomolecules Turn Self-Assembling Amphiphilic Block Co-polymer Platforms Into Biomimetic Interfaces“ Front. Chem. 2019, 6:645. [DOI]
A. Angelini, C. Fodor, W. Yave, L. Leva, A. Car, W. Meier “pH-Triggered Membrane in Pervaporation Process“ ACS Omega 2018. [DOI]
M. Garni, R. Wehr, S. Yorulmaz Avsar, C. John, C. G. PalivanW. Meier “Polymer membranes as templates for bio-applications ranging from artificial cells to active surfaces“ Eur. Polym. J. 2018. [DOI]
E. V. Konishcheva, U. E. Zhumaev, W. Meier “Self-Assembly of PEO-b-PCL-b-PMOXA Binary Mixtures“ Macromolecules 2018. [DOI]
S. Rigo, G. Gunkel-Grabole, W. MeierC. G. Palivan “Surfaces with Dual Functionality through Specific Coimmobilization of Self-Assembled Polymeric Nanostructures“ 2018. [DOI]
M. E. Idrissi, C. E. Meyer, L. Zartner, W. Meier “Nanosensors based on polymer vesicles and planar membranes: a short review“ J. Nanobiotechnol. 2018. [DOI]
M. Garni, T. Einfalt, R. Goers, C. G. PalivanW. Meier “Live follow-up of enzymatic reactions inside the cavities of synthetic giant unilamellar vesicles (GUVs) equipped with membrane proteins mimicking cell architecture“ ACS Synth. Biol. 2018. [DOI]
G. Gunkel-Grabole, W. Meier “Biomimetic Polymer Architectures“ Chimia 2018, 72:548-548. [DOI]
C. L. Draghici, V. Mikhalevich, G. Gunkel-Grabole, J. Kowal, W. MeierC. G. Palivan “Biomimetic planar Polymer Membranes decorated with Enzymes as Functional Surfaces“ Langmuir 2018. [DOI]
R. Goers, J. Thoma, N. Ritzmann, A. Di Silvestro, C. Alter, G. Gunkel-Grabole, D. FotiadisD. J. MüllerW. Meier “Optimized reconstitution of membrane proteins into synthetic membranes“ Commun. Chem. 2018. [DOI]
A. Najer, C. G. Palivan, H. Beck, W. Meier “Challenges in Malaria Management and a Glimpse at Some Nanotechnological Approaches“ Infectious Diseases and Nanomedicine III 2018. [DOI]
J. Gaitzsch, P. C. Welsch, J. Folini, C. Schoenenberger, J. C. Anderson, W. Meier “Revisiting Monomer Synthesis and Radical Ring Opening Polymerization of Dimethylated MDO Towards Biodegradable Nanoparticles for Enzymes“ Eur. Polym. J. 2018. [DOI]
E. Konishcheva, D. Daubian, J. GaitzschW. Meier “Synthesis of Linear ABC Triblock Copolymers and Their Self-Assembly in Solution“ Helv. Chim. Acta 2018. [DOI]
A. Lanzilotto, M. Kyropoulou, E. C. Constable, C. E. HousecroftW. MeierC. G. Palivan “Porphyrin-polymer nanocompartments: singlet oxygen generation and antimicrobial activity“ 2017. [DOI]
J. Gaitzsch, L. Messager, E. Morecroft, W. Meier “Vesicles in Multiple Shapes: Fine-Tuning Polymersomes’ Shape and Stability by Setting Membrane Hydrophobicity“ Polymers 2017, 9(10):483. [DOI]
E. V. Konishcheva, U. E. Zhumaev, M. Kratt, V. Oehri, W. Meier “Complex Self-Assembly Behavior of Bis-hydrophilic PEO-b-PCL-b-PMOXA Triblock Copolymers in Aqueous Solution“ Macromolecules 2017. [DOI]
C. Edlinger, T. Einfalt, M. Spulber, A. Car, W. MeierC. G. Palivan “Biomimetic Strategy To Reversibly Trigger Functionality of Catalytic Nanocompartments by the Insertion of pH-Responsive Biovalves“ Nano Lett. 2017. [DOI]
V. Mikhalevich, I. Craciun, M. Kyropoulou, C. G. PalivanW. Meier “Amphiphilic peptide self-assembly: Expansion to hybrid materials“ Biomacromolecules 2017. [DOI]
G. Gunkel-Grabole, C. G. PalivanW. Meier “Nanostructured Surfaces through Immobilization of Self-Assembled Polymer Architectures Using Thiol–Ene Chemistry“ Macromol. Mater. Eng. 2017, 302:1600363. [DOI]
I. Craciun, G. Gunkel-Grabole, A. Belluati, C. G. PalivanW. Meier “Expanding the potential of MRI contrast agents through multifunctional polymeric nanocarriers“ Nanomedicine 2017, 12:811-17. [DOI]
S. MatileW. MeierC. G. Palivan “Strain-Promoted Thiol-Mediated Cellular Uptake of Giant Substrates: Liposomes and Polymersomes“ Angew. Chem. Int. Ed. 2017, 56:2947-50. [DOI]
S. Lörcher, W. Meier “Cosolvent fractionation of PMOXA-b-PDMS-b-PMOXA: Bulk separation of triblocks from multiblocks“ Eur. Polym. J. 2017. [DOI]
P. Baumann, M. Spulber, O. Fischer, A. Car, W. Meier “Investigation of Horseradish Peroxidase Kinetics in an “Organelle-Like” Environment“ Small 2017, 13:1603943. [DOI] [More Information]
E. V. Konishcheva, U. E. Zhumaev, W. Meier “PEO-b-PCL-b-PMOXA Triblock Copolymers: From Synthesis to Microscale Polymersomes with Asymmetric Membrane“ Macromolecules 2017. [DOI]
J. Liu, V. Postupalenko, S. Lörcher, D. Wu, M. Chami, W. MeierC. G. Palivan “DNA-Mediated Self-Organization of Polymeric Nanocompartments Leads to Interconnected Artificial Organelles“ Nano Lett. 2016:DOI: 10.1021/acs.nanolett.6b03430. [DOI] [More Information]
D. Vasquez, T. Einfalt, W. MeierC. G. Palivan “Asymmetric Triblock Copolymer Nanocarriers for Controlled Localization and pH-Sensitive Release of Proteins“ Langmuir 2016, 32:10235-43. [DOI]
S. J. Sigg, F. Santini, A. Najer, P. U. Richard, W. MeierC. G. Palivan “Nanoparticle-based highly sensitive MRI contrast agents with enhanced relaxivity in reductive milieu“ Chem. Commun. 2016, 52:9937-40. [DOI]
D. Harder, S. Hirschi, Z. Ucurum, R. Goers, W. MeierD. J. MüllerD. Fotiadis “Engineering a Chemical Switch into the Light-driven Proton Pump Proteorhodopsin by Cysteine Mutagenesis and Thiol Modification“ Angew. Chem. Int. Ed.  2016, 55:8846. [DOI]
A. Najer, D. Wu, M. G. Nussbaumer, G. Schwertz, A. Schwab, M. C. Witschel, A. Schäfer, F. Diederich, M. Rottmann, C. G. Palivan, H. Beck, W. Meier “An amphiphilic graft copolymer-based nanoparticle platform for reduction-responsive anticancer and antimalarial drug delivery“ Nanoscale 2016:DOI: 10.1039/C6NR04290B. [DOI]
S. HirschiM. Stauffer, D. Harder, D. J. MüllerW. MeierD. Fotiadis “Engineering and Assembly of Protein Modules into Functional Molecular Systems“ Chimia 2016, 6:398. [DOI]
Y. Cotelle, N. Chuard, S. Lascano, V. Lebrun, R. Wehlauch, N. Bohni, S. Lörcher, V. Postupalenko, S. ReddyW. MeierC. G. Palivan, K. Gademann, T. R. WardS. Matile “Interfacing Functional Systems“ Chimia 2016, 6:418. [DOI]
C. E. HousecroftC. G. Palivan, K. Gademann, W. Meier, M. Calame, V. Mikhalevich, X. Zhang, E. Piel, M. Szponarski, A. Wiesler, A. Lanzilotto, E. C. Constable, A. Fanget, R. Stoop “‘Active surfaces’ as Possible Functional Systems in Detection and Chemical (Bio) Reactivity“ Chimia 2016, 6:402. [DOI]
M. Garni, T. Einfalt, M. Lomora, A. Car, W. MeierC. G. Palivan “Artificial Organelles: Reactions inside Protein–Polymer Supramolecular Assemblies“ Chimia 2016, 6:424. [DOI]
V. Mikhalevich, C. Zelmer, A. Car, C. G. PalivanW. Meier “Bio-inspired Polymer Membranes“ Bio-inspired Polymers 2016, 22:221-58. [DOI]
I. A. Dinu, J. T. Duskey, A. Car, C. G. PalivanW. Meier “Engineered non-toxic cationic nanocarriers with photo-triggered slow-release properties“ Polym. Chem. 2016, 7:3451. [DOI]
A. Najer, S. Thamboo, C. G. Palivan, H. Beck, W. Meier “Giant Host Red Blood Cell Membrane Mimicking Polymersomes Bind Parasite Proteins and Malaria Parasites“ Chimia 2016, 4:288. [DOI]
S. J. Sigg, V. Postupalenko, J. T. Duskey, C. G. PalivanW. Meier “Stimuli-Responsive Codelivery of Oligonucleotides and Drugs by Self-Assembled Peptide Nanoparticles“ Biomacromolecules 2016, 17:935-45. [DOI]
X. Zhang, M. Lomora, T. Einfalt, W. Meier, N. Klein, D. Schneider, C. G. Palivan “Active surfaces engineered by immobilizing protein-polymer nanoreactors for selectively detecting sugar alcohols“ Biomaterials 2016, 89:79. [DOI]
G. Gunkel-Grabole, A. Car, V. V. Naik, L. Marot, G. Ferk, C. G. PalivanW. Meier “PEG Brushes on Porous, PDMS-Coated Surfaces and Their Interaction with Carbon Dioxide“ Macromol. Chem. Phys. 2016, 217:966. [DOI]
C. G. Palivan, R. Goers, A. Najer, X. Zhang, A. Car, W. Meier “Bioinspired polymer vesicles and membranes for biological and medical applications“ Chem. Soc. Rev. 2015, 45:377. [DOI]
A. Najer, S. Thamboo, J. T. Duskey, W. MeierC. G. Palivan “Analysis of Molecular Parameters Determining the Antimalarial Activity of Polymer-Based Nanomimics“ Macromol. Rapid Commun. 2015, 36:1923. [DOI]
J. Liu, V. Postupalenko, J. T. Duskey, C. G. PalivanW. MeierV. Mikhalevich “pH-Triggered Reversible Multiple Protein-Polymer Conjugation Based on Molecular Recognition“ J. Chem. Phys. B. 2015, 119:12066. [DOI]
G. Tsiavaliaris, F. Itel, K. Hedfalk, S. Al-Samir, W. Meier, G. Gros, V. Endeward “Low CO2 permeability of cholesterol-containing liposomes detected by stopped-flow fluorescence spectroscopy“ FASEB J. 2015, 29:1780. [DOI]
F. Itel, A. Najer, C. G. PalivanW. Meier “Dynamics of Membrane Proteins within Synthetic Polymer Membranes with Large Hydrophobic Mismatch“ Nano Lett. 2015, 15:3871. [DOI] [More Information] [Artikel in ChimieXtra]
J. Kowal, D. Wu, V. MikhalevichC. G. PalivanW. Meier “Hybrid Polymer–Lipid Films as Platforms for Directed Membrane Protein Insertion“ Langmuir 2015, 31:4868. [DOI]
T. Schuster, M. Nussbaumer, P. Baumann, N. Bruns, W. Meier, A. Car “Polymeric particulates for subunit vaccine delivery“ Subunit Vaccine Delivery 2015:181-201. [DOI]
G. Gunkel-Grabole, S. Sigg, M. Lomora, S. Lörcher, C. G. PalivanW. Meier “Polymeric 3D nano-architectures for transport and delivery of therapeutically relevant biomacromolecules“ Biomater. Sci. 2015, 2:25. [DOI]
A. Najer, D. Wu, A. Bieri, F. Brand, C. G. Palivan, H. P. Beck, W. Meier “Nanomimics of Host Cell Membranes Block Invasion and Expose Invasive Malaria Parasites“ ACS Nano 2014, 8:12560. [DOI] [More Information]
F. Itel, M. Chami, A. Najer, S. Lörcher, D. Wu, I. A. Dinu, W. Meier “Molecular organization and dynamics in polymersome membranes: A lateral diffusion study“ Macromolecules 2014, 47:7588. [DOI]
D. Wu, M. Spulber, F. Itel, M. Chami, T. Pfohl, C. G. PalivanW. Meier “Effect of Molecular Parameters on the Architecture and Membrane Properties of 3D Assemblies of Amphiphilic Copolymers“ Macromolecules 2014, 47:5060-69. [DOI]