Yaakov Benenson - NCCR MSE

Yaakov Benenson

Department of Biosystems Science and Engineering (D-BSSE), ETH Zurich

Project Leader


S. Tarvirdipour, M. Skowicki, C. Schoenenberger, L. E. Kapinos, R. Y. H. Lim, Y. BenensonC. G. Palivan “A self-assembling peptidic platform to boost the cellular uptake and nuclear delivery of oligonucleotides“ Biomater. Sci. 2022. [DOI]
L. Prochazka, Y. S. Michaels, C. Lau, R. D. Jones, M. Siu, T. Yin, D. Wu, E. Jang, M. Vázquez-Cantú, P. M. Gilbert, H. Kaul, Y. Benenson, P. W. Zandstra “Synthetic gene circuits for cell state detection and protein tuning in human pluripotent stem cells“ Mol. Syst. Biol. 2022. [DOI]
Y. Benenson “An AAV gene therapy computes over multiple cellular inputs to enable precise targeting of multifocal hepatocellular carcinoma in mice“ Sci. Transl. Med. 2021. [DOI]
R. Altamura, J. Doshi, Y. Benenson “Rational design and construction of multi-copy biomanufacturing islands in mammalian cells“ Nucleic Acids Res. 2021. [DOI]
J. Doshi, K. Willis, A. Madurga, C. Stelzer, Y. Benenson “Multiple Alternative Promoters and Alternative Splicing Enable Universal Transcription-Based Logic Computation in Mammalian Cells“ Cell Rep. 2020. [DOI]
S. Höllerer, L. Papaxanthos, A. C. Gumpinger, K. Fischer, C. Beisel, K. Borgwardt, Y. Benenson, M. Jeschek “Large-Scale DNA-Based Phenotypic Recording and Deep Learning Enable Highly Accurate Sequence-Function Mapping“ Nat. Commun. 2020. [DOI]
A. Mazé, Y. Benenson “Artificial signaling in mammalian cells enabled by prokaryotic two-component system“ Nat. Chem. Biol. 2019. [DOI]
M. Dastor, J. Schreiber, L. Prochazka, B. Angelici, J. Kleinert, I. Klebba, J. Doshi, L. Shen, Y. Benenson “A Workflow for In Vivo Evaluation of Candidate Inputs and Outputs for Cell Classifier Gene Circuits“ ACS Synth. Biol. 2017. [DOI]
L. Prochazka, Y. Benenson, P. W. Zandstra “Synthetic gene circuits and cellular decision-making in human pluripotent stem cells“ Curr. Opin. Syst. Biol. 2017. [DOI]
P. Mohammadi, N. Beerenwinkel, Y. Benenson “Automated Design of Synthetic Cell Classifier Circuits Using a Two-Step Optimization Strategy“ 2017. [DOI]
J. Schreiber, M. Arter, N. Lapique, B. Haefliger, Y. Benenson “Model‐guided combinatorial optimization of complex synthetic gene networks“ Mol. Syst. Biol. 2016, 12:899. [DOI]
Y. Benenson “Complexity from Simple Building Blocks: Engineering Large-scale Information-processing Networks from Molecules“ Chimia 2016, 6:392. [DOI]
B. Häfliger, L. Prochazka, B. Angelici, Y. Benenson “Precision multidimensional assay for high-throughput microRNA drug discovery“ Nat. Commun. 2016, 7:DOI: 10.1038/ncomms10709. [DOI] [More Information]