SeminBar

  • Sonja Kleinlogel will talk on 6 March 2018  Sud.
    Sonja Kleinlogel will talk on 6 March 2018 Sud.
  • Sergio Pires will "surround" the talk on 6 March with his clarinet.
    Sergio Pires will "surround" the talk on 6 March with his clarinet.
  • SeminBar/Jam with Cees Dekker on 20.9.2016.
    SeminBar/Jam with Cees Dekker on 20.9.2016.
  • SeminBar/Jam with Cees Dekker on 20.9.2016.
    SeminBar/Jam with Cees Dekker on 20.9.2016.
  • The British Pub-Night at the SeminBar on 10 May 2016: After the talk by Philipp Holliger, "Thom Dudelsackspieler" and a pub-quiz rounded up the evening.
    The British Pub-Night at the SeminBar on 10 May 2016: After the talk by Philipp Holliger, "Thom Dudelsackspieler" and a pub-quiz rounded up the evening.
  • Afterparty at SeminBar on 26 November at Ackermannshof: Members of the NCCR Molecular Systems Engineering and other guests jam with the students from the Jazz Campus Basel.
    Afterparty at SeminBar on 26 November at Ackermannshof: Members of the NCCR Molecular Systems Engineering and other guests jam with the students from the Jazz Campus Basel.
  • Afterparty at SeminBar on 26 November at Ackermannshof: Members of the NCCR Molecular Systems Engineering and other guests jam with the students from the Jazz Campus Basel.
    Afterparty at SeminBar on 26 November at Ackermannshof: Members of the NCCR Molecular Systems Engineering and other guests jam with the students from the Jazz Campus Basel.
  • Afterparty at SeminBar on 26 November at Ackermannshof: Members of the NCCR Molecular Systems Engineering and other guests jam with the students from the Jazz Campus Basel.
    Afterparty at SeminBar on 26 November at Ackermannshof: Members of the NCCR Molecular Systems Engineering and other guests jam with the students from the Jazz Campus Basel.
  • Afterparty at SeminBar on 26 November at Ackermannshof: Members of the NCCR Molecular Systems Engineering and other guests jam with the students from the Jazz Campus Basel.
    Afterparty at SeminBar on 26 November at Ackermannshof: Members of the NCCR Molecular Systems Engineering and other guests jam with the students from the Jazz Campus Basel.

The SeminBar brings new know-how on molecular systems engineering to researchers and the interested public alike. The SeminBar on 6 March 2018 features PD Dr. Sonja Kleinlogel.

The NCCR Molecular Systems Engineering unites 27 active research projects with close to 100 researchers in an interdisciplinary approach. The diversity of the researchers and the various universities and institutes involved guarantee cross-fertilization in a stimulating working environment. To strive for the best results, it is vital to have a 360 degree vision, while simultaneously remaining focussed on this NCCR.

To inspire and to bring an outside view into the NCCR Molecular Sys-tems Engineering, SeminBar regularly features international scientists talking about their research emphasising key scientific concepts rele-vant to molecular systems engineering. Students introduce the speakers.

The SeminBar at Sud in Basel is in English and starts at 6 pm. It is open to the public. No reservations are necessary. After the talk, starting at 9 pm, students organise various cultural events.

SeminBar on 6 March 2018 @ Sud

Sonja Kleinlogel

When light and viruses may heal us: a glimpse behind the scenes of clinical research

PD Dr. Sonja Kleinlogel leads the Optogenetics Laboratory at the Institute of Physiology of the University of Bern where she develops new gene therapy approaches to treat blindness. This SeminBar will give insights into customizing optogenetic and gene therapeutic vehicles by protein engineering with the goal to optimize a clinical gene therapy for the restoration of vision. 

Optogenetics technology, which came to life in 2003, has revolutionized neuroscience research. The optogenetic strategy relies on the use of light-sensitive proteins (e.g. microbial opsins) to render a specific target cell photosensitive. When expressed on the surface of a neuron, optogenetic proteins trigger an ionic current through the plasma membrane upon light stimulation, leading to neuronal depolarization, i.e. activation and spiking, or neuronal hyperpolarization, i.e. silencing.  One clinical optogenetic research direction, which entered clinical trials in 2016, is the restoration of vision. Every year millions of people are affected by diseases leading to photoreceptor degeneration and ultimately blindness. Losing the ability to see is devastating for the affected patients, in particular since no cure exists and has spurred the development of optogenetic gene therapies to restore vision.

Using optogenes to cure blindness has the advantage of having a “one-size-fits-all” aspect and works for any type of photoreceptor degeneration at any stage of disease. Being a cell-specific therapy, high quality of vision such as face and object recognition can, in principle, be restored.

The optogenes are delivered by a viral gene therapy. The only virus small enough to penetrate through the dense retinal tissue is the adeno-associated virus (AAV). AAV is a very small, non-pathogenic virus that is typically hitching a ride into our bodies with adenovirus, the latter causing typical cold symptoms. About 90 percent of people are infected with asymptomatic AAV and due to its limited capacity to induce immune responses in humans, the AAV capsid presents the perfect “taxi” to shuttle an optogene to the desired cell.

This SeminBar will be about optogenetic and viral protein engineering in light of realizing an optogenetic clinical gene therapy for the restoration of vision. Dr. Kleinlogel will outlay the advantages, present achievements and future possibilities and finally discuss the hurdles still to be overcome before this methodology will potentially be implemented in clinical practice.

SeminBar 6 March with classical music

Sergio Pires plays the clarinet.

The talk by Sonja Kleinlogel will be "surrounded" by a classical music performance: Sergio Pires (Musikkollegium Winterthur) will open the evening with his clarinet, and return for a second performance later in the evening. Everyone welcome.

Previous SeminBar-Speakers

2 Nov. 2017: Prof. Bradley Hyman
Bradley Hyman is a Professor of Neurology at the Massachusetts General Hospital, Harvard Medical School. He talked about "Alzheimer’s disease: snapshots from the journey towards a cure". Read more in the event-flyer.

25 January 2017: Prof. Dirk Trauner
Prof. Dirk Trauner from the New York University (NYU) talked about “Synthetic Photobiology”. 
Read more in the event-flyer.

30 November 2016: Prof. Anthony J. Ryan
Prof. Ryan from the University of Sheffield/UK talked about "3 Millenia of Condoms",  and on the material properties of rubber, and the place of condoms in popular culture. Read more in the event-flyer here.

20 September 2016: Prof. Cees Dekker
Prof. Dekker from the Delft University of Technology talked about "What is life, and how does life differ from non-life?" Later, Cees Dekker jammed with students onstage. Read more here.

10 May 2016: Philipp Holliger
Philipp Holliger - MRC Laboratory of Molecular Biology - talked about "A Synthetic Biology Approach to Abiogenesis". Read more here.

26 November 2015: Dr. Philippe Marlière
Dr. Philippe Marlière is the founder of Synthetic- and Xeno-Biology. “Accept No Limits” was the title of his speech. Read more here.

28 October 2015: Prof. Dr. Andreas Plückthun
Prof. Dr. Andreas Plückthun, Director at the Departement of Biochemistry at University of Zurich, spoke at the third SeminBar on 28 October 2015 about "Influencing cells with man-made proteins". Read more here.

Prof. Dr. Markus Antonietti's artistic vision of artificial trees producing energy.

7 May 2015: Prof. Dr. Markus Antonietti
Prof. Dr. Markus Antonietti from the Max Planck Institute of Colloids and Interfaces in Potsdam-Golm spoke at the second SeminBar on 7 May 2015 about "Black and Orange Magic". Read more here

DNA Origami Wallpaper

14 January 2015: Prof. Dr. Hendrik Dietz
The first SeminBar took place on 14.1.2015 with a public lecture by Prof. Dr. Hendrik Dietz from TU Munich on “Molecular Systems Engineering with DNA”. Read more here.

NEW: SeminBar @ SUD

SeminBar now welcomes you at Sud, Burgweg 7, 4058 Basel.

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Media on SeminBar

Read articles on previous SeminBar-events here, while media-releases are available here.

SeminBar-Contact:

Claude R. Etique, Head Communication.